The National Guidelines for HIV Care and Treatment 2021 provides a comprehensive set of recommendations for HIV management in adults and children geared to achieve the 95-95-95 targets by 2030 including recent amendments and changes in treatment and newer innovations. The guidelines are primarily intended for medical officers of ART centres across the country and clinicians in the public or private sectors who tend to provide services to the people living with HIV (PLHIV). These guidelines are used as a reference manual for in-service health provider education and training; as a source of up-to-date, evidence-based recommendations; and as a self-education tool for health care providers on the prevention, diagnosis, and treatment of HIV/AIDS.